Akademik Veri Yönetim Sistemi
2nd International Epigenetics Congress, İstanbul, Türkiye, 2 - 03 Eylül 2023, ss.10
Background: In Phase 1 of liver detoxification, toxic substances are converted into more toxic intermediate metabolites. In phase 2, these intermediate metabolites are converted into water-soluble substances such as bile or urea and are excreted from the body. Cytochrome P450 (CYP450), Glutathione-S-Transferase (GST), Catechol-O-Methyl Transferase (COMT) are among some of the biotransformation enzymes involved in phase1-2 stages. It has been observed that nutraceuticals such as quercetin can alter the functioning of these enzymes. Objective: This study was conducted to explain the effect of quercetin on some detoxification genes. Methods: Studies published between January 1990 and July 2023 examining the effect of quercetin on genes encoding detoxification enzymes were searched in various databases (PubMed, Scopus). Results: In a study investigating the effects of quercetin on 7,12-dimethylbenz(a)anthracene(DMBA)-induced oxidative stress and CYP1A1/B1 expression in mice, quercetin showed antioxidant properties by helping to regulate oxidative stress caused by DMBA. It has also been found to have a protective effect by suppressing CYP1A1/B1 enzymes. In another study, upregulation of GSTs and downregulation of CYP450s was observed with the consumption of foods rich in quercetin. Frequent intake of quercetin-rich foods was inversely associated with lung cancer risk. In addition, the effect of quercetin on 17β-estradiol (E2)-induced breast cancer was examined. It has been noted that quercetin does not protect against breast cancer, does not inhibit E2-induced oxidant stress, and may exacerbate mammary carcinogenesis in E2-treated ACI rats. Conclusions & Discussion: Quercetin inhibits CYP1A1/B1 and COMT enzymes and induces GST enzymes. This shows that in addition to CYP and GST genes, attention should be paid to the COMT gene status of the person while taking quercetin. Quercetin is thought to have a negative effect when the COMT enzyme works slowly. Therefore, it is not necessary to take supplements according to a single gene, but to be considered polygenic.
Keywords: quercetin, detoxification, cytochrome-P-450, GST, COMT