Influence on some rumex extracts on histamine and prostaglandin levels in rat gut

KANZIK İ., ŞENER B., AKAR F., Şatiroǧlu Ş., Karakoç H.

Pharmaceutical Biology, vol.26, no.3, pp.173-177, 1988 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 3
  • Publication Date: 1988
  • Doi Number: 10.3109/13880208809053914
  • Journal Name: Pharmaceutical Biology
  • Journal Indexes: Scopus
  • Page Numbers: pp.173-177
  • Gazi University Affiliated: Yes


Rumex species have been examined for their effects on gastrointestinal functions. R. alpinus L. and R. crispus L. found most potent in intestinal motility studies, together with some purgative drugs, were further investigated for their effects on the formation of histamine and prostaglandin-like material (PG-lm) by rat intestine in vivo. The results show that the Rumex species possess some laxative effect due at least in part to increased intestinal production of histamine and PG-lm. © 1988 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.