Scientific and technological developments triggered creative thinking and the emergence of innovative products in many fields such as art, architecture, engineering, nanotechnology, and medicine. The main reason behind this might be the formation of new dynamics by blurring the sharp distinctions between disciplines. Different meanings and concepts with the changing dynamics also lead to the reshaping of interdisciplinary relations. The effects of bio-inspired/bio-informed paradigms in many disciplines including art have been analyzed. The first part of this study presents the traces of the environment with examples from the prominent movements in the art of painting developed in the period from the first works of humanity to the middle of the 20th century. Second, paintings, sculptures, and installations shaped by the understanding of bio-art that has become widespread in recent years are included. It was understood that art has experienced paradigmatic shifts as a result of interdisciplinary relations with fields such as technology, biology, synthetic biology, and biotechnology, and this interaction with established connections led to the development of innovative approaches in art.