Anti-ulcerogenic activity and isolation of the active principles from Sambucus ebulus L. leaves

YEŞİLADA E., GÜRBÜZ İ., Toker G.

JOURNAL OF ETHNOPHARMACOLOGY, cilt.153, sa.2, ss.478-483, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 153 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.jep.2014.03.004
  • Dergi Adı: JOURNAL OF ETHNOPHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.478-483
  • Anahtar Kelimeler: Antiulcerogenic activity, Flavonoids, Isoquercitrin, Isorhamnetin-3-O-glucoside, Peptic ulcer, Sambucus ebulus L, TRADITIONAL MEDICINE, FOLK MEDICINE, TURKEY, GLYCOSIDES, EXTRACT, STRESS, PLANTS
  • Gazi Üniversitesi Adresli: Evet

Özet

Ethnopharmacological relevance: Sambucus ebulus L. has a very prominent place in Turkish folk medicine. Leaves of the plant are practiced externally to relieve rheumatic pain, to treat abscess, for wound healing and internally against hemorrhoids and stomachache. In a previous work, aqueous extract of the leaves was shown to possess potent antiulcerogenic activity on water immersion and immobilization-induced stress ulcer model in rats. This study aims to investigate the antiulcerogenic activity profile of the plant on various in vivo peptic ulcer models and gastric biochemical parameters and through bioassay-guided processing to isolate the active constituent (s) and to elucidate its structure.