Assessment of atherosclerosis risk due to the homocysteine-asymmetric dimethylarginine-nitric oxide cascade in children taking antiepileptic drugs


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Emeksiz H. C. , SERDAROĞLU A., BİBEROĞLU G., GÜLBAHAR Ö., ARHAN E., CANSU A., ...More

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, vol.22, no.2, pp.124-127, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 2
  • Publication Date: 2013
  • Doi Number: 10.1016/j.seizure.2012.11.007
  • Journal Name: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.124-127
  • Keywords: Antiepileptics, Atherosclerosis, Homocysteine, Asymmetric dimethylarginine, Nitric oxide, EPILEPTIC CHILDREN, FOLIC-ACID, ENDOTHELIAL DYSFUNCTION, PLASMA HOMOCYSTEINE, CARDIOVASCULAR RISK, SERUM-LIPIDS, HYPERHOMOCYSTEINEMIA, VALPROATE, VITAMIN-B12, PATHWAY
  • Gazi University Affiliated: Yes

Abstract

Purpose: The aim of this study was to assess the atherogenicity risk of antiepileptics in children by investigating the cascade, "hyperhomocysteinemia (HHcy) -> asymmetric dimethylarginine (ADMA) increase -> nitric oxide (NO) decrease", which is thought to contribute to the developmental process of atherosclerosis.