Assessment of atherosclerosis risk due to the homocysteine-asymmetric dimethylarginine-nitric oxide cascade in children taking antiepileptic drugs

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Emeksiz H. C., SERDAROĞLU A., BİBEROĞLU G., GÜLBAHAR Ö., ARHAN E., CANSU A., ...Daha Fazla

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, cilt.22, sa.2, ss.124-127, 2013 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.seizure.2012.11.007
  • Dergi Adı: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.124-127
  • Anahtar Kelimeler: Antiepileptics, Atherosclerosis, Homocysteine, Asymmetric dimethylarginine, Nitric oxide, EPILEPTIC CHILDREN, FOLIC-ACID, ENDOTHELIAL DYSFUNCTION, PLASMA HOMOCYSTEINE, CARDIOVASCULAR RISK, SERUM-LIPIDS, HYPERHOMOCYSTEINEMIA, VALPROATE, VITAMIN-B12, PATHWAY
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Gazi Üniversitesi Adresli: Evet

Özet

Purpose: The aim of this study was to assess the atherogenicity risk of antiepileptics in children by investigating the cascade, "hyperhomocysteinemia (HHcy) -> asymmetric dimethylarginine (ADMA) increase -> nitric oxide (NO) decrease", which is thought to contribute to the developmental process of atherosclerosis.