After the beginning of the First World War, the Ottoman state declared mobilization, but various Armenian communities, and especially the Zeitun Armenians, did not obey these orders. While certain Armenians who had previously joined the army escaped from their military duties, others served the Russian army against the Ottomans. The Zeitun Armenians started rebellion against the Ottomans both before and during the war, thinking that they could win their independence once the Entente States won the war. They therefore forced some sections of the Ottoman army to struggle with inner security, keeping them away from the fighting front. In this study, the relations between Zeitun Armenians and Entente States, and the causes and effects of their rebellions will be investigated.