Atrophic and regenerative changes in rabbit mimic muscles after lidocaine and bupivacaine application

Calguner, E; Gozil, R; Erdogan, D; Kurt, I; Keskil, S; Elmas, ÇİĞDEM; Sabuncuoglu, H

doi:10.1046/j.1439-0264.2003.00439.x

Atrophic and regenerative changes in rabbit mimic muscles after lidocaine and bupivacaine application

Atıf İçin Kopyala

Calguner E., Gozil R., Erdogan D., Kurt I., Keskil S., Elmas Ç., ...Daha Fazla

Journal of Veterinary Medicine Series C: Anatomia Histologia Embryologia, cilt.32, sa.1, ss.54-59, 2003 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 32 Sayı: 1
Basım Tarihi: 2003
Doi Numarası: 10.1046/j.1439-0264.2003.00439.x
Dergi Adı: Journal of Veterinary Medicine Series C: Anatomia Histologia Embryologia
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.54-59
Gazi Üniversitesi Adresli: Evet

Özet

Destruction and denervation atrophy in skeletal muscles caused by the injection of local anaesthetics was investigated by injecting lidocaine or bupivacaine around the rabbit facial nerve to produce facial paralysis. Animals were then sacrificed at 2, 4, 6, and 8 weeks post-injection, and changes in mimic muscle tissue were assessed at each stage by light microscopy and electron microscopy. Atrophic changes were observed at 2-6 weeks after injection, and regeneration started at 6-8 weeks. Compared to bupivacaine, lidocaine caused more dramatic atrophic changes and was associated with slower muscle regeneration.