The effects of ascorbic acid on penicillin-induced epileptiform activity in rats

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Ayyildiz M., Coskun Ş., Yildirim M., Agar E.

EPILEPSIA, vol.48, no.7, pp.1388-1395, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 7
  • Publication Date: 2007
  • Doi Number: 10.1111/j.1528-1167.2007.01080.x
  • Journal Name: EPILEPSIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1388-1395
  • Keywords: epileptiform activity, glutathione, lipid peroxidation, penicillin, vitamin C, LIPID-PEROXIDATION, GLUTATHIONE-PEROXIDASE, OXIDATIVE STRESS, TRACE-ELEMENTS, FREE-RADICALS, IN-VITRO, ETHANOL, ELECTROLYTES, HIPPOCAMPUS, SYSTEMS
  • Gazi University Affiliated: Yes

Abstract

Purpose: Epileptic seizure results from excessive discharge in a population of hyperexcitable neurons. A number of studies help to document the effects of active oxygen free radical scavengers such as alpha-tocopherol or ascorbic acid (vitamin C). In the present study, we examined the effects of ascorbic acid, at the six different doses, on penicillin-induced epileptiform activity.