Novel antifouling oligo(ethylene glycol) methacrylate particles via surfactant-free emulsion polymerization

Buyukserin F., Camli S. T., Yavuz M. S., Budak G. G.

JOURNAL OF COLLOID AND INTERFACE SCIENCE, cilt.355, sa.1, ss.76-80, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 355 Sayı: 1
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.jcis.2010.11.081
  • Dergi Adı: JOURNAL OF COLLOID AND INTERFACE SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.76-80
  • Anahtar Kelimeler: Poly(ethylene glycol) ethyl ether methacrylate, Cross-linked, Surfactant-free emulsion polymerization, Antifouling, Albumin adsorption, BOVINE SERUM-ALBUMIN, POLY(ETHYLENE GLYCOL), SILICA NANOPARTICLES, GENE DELIVERY, CROSS-LINKER, HUMAN PLASMA, ADSORPTION, PH, COPOLYMERIZATION, MICROBEADS
  • Gazi Üniversitesi Adresli: Evet

Özet

The use of particle formulations with antifouling surface properties attracts increasing interest in several biotechnological applications. Majority of these studies utilize a poly(ethylene glycol) coating to render the corresponding surface nonrecognizable to biological macromolecules. Herein, we report a simple way to prepare novel antifouling colloids composed of oligo(ethylene glycol) backbones via surfactant-free emulsion polymerization. Monodisperse cross-linked poly(ethylene glycol) ethyl ether methacrylate particles were characterized by dynamic light scattering and transmission electron microscopy. The effects of monomer, cross-linker and initiator on particle characteristics were investigated. More importantly, a prominent blockage of bovine serum albumin adsorption was obtained for the poly(ethylene glycol)-based sub-micron (similar to 200 nm) particles when compared with similar-sized poly(methyl methacrylate) counterparts. (C) 2010 Elsevier Inc. All rights reserved.