Pantoprazole-Na release from poly(acrylamide-co-crotonic acid) and poly(acrylic acid-co-crotonic acid) hydrogels

PULAT M. , Cetin M.

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, vol.23, no.4, pp.3054-318, 2008 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 4
  • Publication Date: 2008
  • Doi Number: 10.1177/0883911508090201
  • Title of Journal : JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
  • Page Numbers: pp.3054-318
  • Keywords: hydrogels, acrylic acid, acrylamide, crotonic acid, hydrogel swelling, pantoprazole, non-Fickian diffusion, controlled release, DRUG-DELIVERY, TERBINAFINE HYDROCHLORIDE, SWELLING BEHAVIOR, IN-VITRO, WATER, DIFFUSION, METHACRYLATE, ITACONATE), NETWORKS

Abstract

Poly(acrylamide-co-crotonic acid) (PAAmCA), poly(acrylic acid-co-crotonic acid) (PAACA), PAA and PAAm hydrogels were prepared by free radical polymerization and ethylene glycol dimethacrylate ( EGDMA) as a crosslinker. The variations of swelling values (%) with time, temperature, and pH were determined for four types of hydrogels. The PAACA hydrogel was swollen 2300% at pH 7.4 and 37 degrees C. The drug release from pantoprazole-Na loaded PAACA and PAAmCA hydrogels was followed at pH 7.4, 37 degrees C for 30 h. The release from PAACA hydrogel was faster than that from PAAmCA hydrogel; therapeutic levels for both hydrogels are obtained within 1 hour. Non-Fickian diffusion was determined for both hydrogels.