Pantoprazole-Na release from poly(acrylamide-co-crotonic acid) and poly(acrylic acid-co-crotonic acid) hydrogels

PULAT M., Cetin M.

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, cilt.23, sa.4, ss.3054-318, 2008 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 4
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1177/0883911508090201
  • Dergi Adı: JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3054-318
  • Anahtar Kelimeler: hydrogels, acrylic acid, acrylamide, crotonic acid, hydrogel swelling, pantoprazole, non-Fickian diffusion, controlled release, DRUG-DELIVERY, TERBINAFINE HYDROCHLORIDE, SWELLING BEHAVIOR, IN-VITRO, WATER, DIFFUSION, METHACRYLATE, ITACONATE), NETWORKS
  • Gazi Üniversitesi Adresli: Evet

Özet

Poly(acrylamide-co-crotonic acid) (PAAmCA), poly(acrylic acid-co-crotonic acid) (PAACA), PAA and PAAm hydrogels were prepared by free radical polymerization and ethylene glycol dimethacrylate ( EGDMA) as a crosslinker. The variations of swelling values (%) with time, temperature, and pH were determined for four types of hydrogels. The PAACA hydrogel was swollen 2300% at pH 7.4 and 37 degrees C. The drug release from pantoprazole-Na loaded PAACA and PAAmCA hydrogels was followed at pH 7.4, 37 degrees C for 30 h. The release from PAACA hydrogel was faster than that from PAAmCA hydrogel; therapeutic levels for both hydrogels are obtained within 1 hour. Non-Fickian diffusion was determined for both hydrogels.