The Role of Extended New Red Blood Cell Parameters on the First Day of Moderate to High-Risk Newborns

Çomruk A., Kaya Z., Kirkiz Kayalı S., Koçak Ü., Türkyilmaz C., Koç E.

CLINICAL PEDIATRICS, cilt.64, sa.12, ss.1671-1676, 2025 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 64 Sayı: 12
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1177/00099228251356192
  • Dergi Adı: CLINICAL PEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, Public Affairs Index
  • Sayfa Sayıları: ss.1671-1676
  • Gazi Üniversitesi Adresli: Evet

Özet

The extended erythrocyte parameters in modern hematology analyzers on the first day of moderate to high-risk newborns in the neonatal intensive care unit (NICU) were examined. The Turkish Neonatal Society's risk classifications were used to divide the newborns into 2 groups: moderate to high-risk (n = 266) and low-risk (n = 340). Routine and extended erythrocyte parameters were analyzed. Moderate to high-risk neonates had significantly lower mean hemoglobin and higher mean corpuscular volume (MCV) and macrocytic erythrocyte ratios (MACRO-R) compared with low-risk newborns (p < .05). Preterm birth, sepsis, pulmonary complications, maternal preeclampsia, and hyperbilirubinemia were all common in moderate to high-risk newborns. A strong correlation was found between MCV and MACRO-R (r = 0.91). The cut-off values for MCV and MACRO-R in predicting moderate to high-risk newborns were 110 fL and 20%, respectively. Our data suggest that increased MCV and MACRO-R levels may be useful predictors of moderate to high-risk newborns on their first day in the NICU.