Should isolated aberrant right subclavian artery be ignored in the antenatal period? A management dilemma Antenatal dönemde izole aberran sağ subklavyen arter gözardı edilmeli mi? Bir yönetim ikilemi

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Behram M., Çaypınar S. S., Oğlak S. C., Sezer S., Esmer A. Ç.

Turkish Journal of Obstetrics and Gynecology, cilt.18, sa.2, ss.103-108, 2021 (ESCI, Scopus, TRDizin) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.4274/tjod.galenos.2021.69749
  • Dergi Adı: Turkish Journal of Obstetrics and Gynecology
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.103-108
  • Anahtar Kelimeler: Aberrant right subclavian artery, DiGeorge syndrome, Down syndrome, Turner syndrome, prenatal diagnosis, DOWN-SYNDROME, AORTIC-ARCH, PRENATAL-DIAGNOSIS, 22Q11 DELETION, FETUSES, ANOMALIES, 2ND-TRIMESTER, ASSOCIATION, LATERALITY, GESTATION
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Gazi Üniversitesi Adresli: Hayır

Özet

© 2021, Turkish Society of Obstetrics and Gynecology. All rights reserved.Objective: To investigate the frequency and types of chromosomal abnormalities in fetuses with the aberrant right subclavian artery (ARSA) and to evaluate its association with other ultrasonographic findings. Materials and Methods: In all, 11,666 fetal anatomic surveys were performed between March 2014 and March 2020. The cases diagnosed as ARSA were examined. Accompanying ultrasound findings and chromosomal abnormalities were collected. Results: ARSA was detected in 140 fetuses (1.2%). The ARSA appeared isolated in 47.1% (66/140) of cases and the remaining 52.9% (74/140) of cases were associated with cardiac or extracardiac malformations and soft markers. Chromosomal abnormalities were detected in 17.8% (25/140) of all cases. Trisomy 21 was the most common chromosomal anomaly with a prevalence of 11.4% (16/140). The corresponding rate was 3% (2/66) and 18.9% (14/74) for isolated and non-isolated ARSA, respectively. DiGeorge syndrome was detected in 3% (n=2) and Turner syndrome was in 3% (n=2) of the isolated group. ARSA was not an isolated finding in any of the 4 fetuses with trisomy 18. Conclusion: Isolated ARSA may be the only antenatal predictor of trisomy 21 or other chromosomal anomalies, including DiGeorge or Turner syndrome. Hence, visualization of the right subclavian artery should be a part of the fetal anatomic survey and genetic analysis should be recommended even in the absence of associated findings.