TURKISH JOURNAL OF PATHOLOGY, vol.37, no.1, pp.7-17, 2021 (ESCI)
Article / Article
TURKISH JOURNAL OF PATHOLOGY
Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, MEDLINE, Directory of Open Access Journals
Lung adenocarcinoma, EML4-ALK, IGFR1, TTF1, Napsin A, TRANSCRIPTION FACTOR-I, CANCER, CLASSIFICATION, IDENTIFICATION, RECURRENCE, FEATURES, GENE
Gazi University Affiliated:
Objective: Patients with lung adenocarcinoma who harbor ALK gene rearrangements can demonstrate significant clinical benefit with ALK tyrosine kinase inhibitors. Insulin-like growth factor receptor I (IGFR1) is a cellular membrane receptor that is overexpressed in many tumors. It plays an important role in cancer progression and is associated with increased postoperative recurrence and poorer disease-free survival. The aim of this study was to determine the EML4-ALK mutation and IGFR1 expression in lung adenocarcinoma and analyze their prognostic value.