Clinicopathological and Prognostic Significance of the EML4-ALK Translocation and IGFR1, TTF1, Napsin A Expression in Patients with Lung Adenocarcinoma


Bulutay P., AKYÜREK N., MEMİŞ L.

TURKISH JOURNAL OF PATHOLOGY, vol.37, no.1, pp.7-17, 2021 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.5146/tjpath.2020.01503
  • Journal Name: TURKISH JOURNAL OF PATHOLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, MEDLINE, Directory of Open Access Journals
  • Page Numbers: pp.7-17
  • Keywords: Lung adenocarcinoma, EML4-ALK, IGFR1, TTF1, Napsin A, TRANSCRIPTION FACTOR-I, CANCER, CLASSIFICATION, IDENTIFICATION, RECURRENCE, FEATURES, GENE
  • Gazi University Affiliated: Yes

Abstract

Objective: Patients with lung adenocarcinoma who harbor ALK gene rearrangements can demonstrate significant clinical benefit with ALK tyrosine kinase inhibitors. Insulin-like growth factor receptor I (IGFR1) is a cellular membrane receptor that is overexpressed in many tumors. It plays an important role in cancer progression and is associated with increased postoperative recurrence and poorer disease-free survival. The aim of this study was to determine the EML4-ALK mutation and IGFR1 expression in lung adenocarcinoma and analyze their prognostic value.