Hyperthermia and radiotherapy combination for locoregional recurrences of breast cancer: a review

aslan s., ÖZDEMİR N., ŞENDUR M. A. N., eren t., aral p., soykurt e.

Breast Cancer Management, cilt.6, sa.4, ss.117-126, 2017 (ESCI) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 6 Sayı: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.2217/bmt-2017-0011
  • Dergi Adı: Breast Cancer Management
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Sayfa Sayıları: ss.117-126
  • Anahtar Kelimeler: breast cancer, hyperthermia, radiotherapy, LOCAL-REGIONAL RECURRENCE, CHEST-WALL, SUPERFICIAL HYPERTHERMIA, RADIATION-THERAPY, PROGNOSTIC-FACTORS, TUMOR RECURRENCE, RANDOMIZED-TRIAL, PHASE-III, REIRRADIATION, IRRADIATION
  • Gazi Üniversitesi Adresli: Hayır

Özet

Breast cancer is a second common form of malignancy and is one of the leading causes of mortality among cancer patients across the world. Locoregional recurrence occurs in 5-20% of patients despite upfront treatment. Local therapy (surgery plus minus re-irradiation) with or without systemic therapy is generally recommended for management. Local control rates vary; months to years, but a significant percentage lives 5 years. Therefore, treatment strategies to increase response rates are significant. Hyperthermia is one of the most potent radiosensitizers and data from meta-analysis and randomized trials support its use with radiotherapy. This study reviews the biologic rationale and clinical evidence about concomitant use of hyperthermia and radiotherapy in locally-recurrent breast cancer patients.