Atıf İçin Kopyala
Dogulu F., Barun S., Emmez H., Elmas Ç., Onal B., Belen H. B., ...Daha Fazla
TURKISH NEUROSURGERY, cilt.19, sa.4, ss.380-386, 2009 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
19
Sayı:
4
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Basım Tarihi:
2009
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Dergi Adı:
TURKISH NEUROSURGERY
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
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Sayfa Sayıları:
ss.380-386
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Anahtar Kelimeler:
5-nitro-2-(3-phenylpropylamino)-benzoate, Cl channel, Endothelin-1, Cerebral vasospasm, CEREBRAL VASOSPASM, SUBARACHNOID HEMORRHAGE, ACTIVATED CHLORIDE, POTASSIUM CURRENTS, NIFLUMIC ACID, CL, TONE, DEPOLARIZATION, NEUROTOXICITY, NORADRENALINE
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Gazi Üniversitesi Adresli:
Evet
Özet
AIM: Endothelin-1 (ET-1) has been implicated in the pathophysiology of cerebral vasospasm. Chloride (Cl-) channels exist in vascular smooth muscle and activation of these channels leads to depolarization and contraction. The aim of the present study was to test the effect of 5-nitro-2-(3-phenylpropylamino)-benzoate (NPPB), a Cl- channel antagonist, on the ET-1-induced cerebral vasospasm in rabbit basilar artery and thus investigate the contribution of Cl- channels.