Effect of a Chloride Channel Inhibitor, 5-Nitro-2-(3-Phenylpropylamino)-Benzoate, on Endothelin-1 Induced Vasoconstriction in Rabbit Basilar Artery

Dogulu F., Barun S., Emmez H., Elmas Ç., Onal B., Belen H. B., ...More

TURKISH NEUROSURGERY, vol.19, no.4, pp.380-386, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 4
  • Publication Date: 2009
  • Journal Name: TURKISH NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.380-386
  • Keywords: 5-nitro-2-(3-phenylpropylamino)-benzoate, Cl channel, Endothelin-1, Cerebral vasospasm, CEREBRAL VASOSPASM, SUBARACHNOID HEMORRHAGE, ACTIVATED CHLORIDE, POTASSIUM CURRENTS, NIFLUMIC ACID, CL, TONE, DEPOLARIZATION, NEUROTOXICITY, NORADRENALINE
  • Gazi University Affiliated: Yes

Abstract

AIM: Endothelin-1 (ET-1) has been implicated in the pathophysiology of cerebral vasospasm. Chloride (Cl-) channels exist in vascular smooth muscle and activation of these channels leads to depolarization and contraction. The aim of the present study was to test the effect of 5-nitro-2-(3-phenylpropylamino)-benzoate (NPPB), a Cl- channel antagonist, on the ET-1-induced cerebral vasospasm in rabbit basilar artery and thus investigate the contribution of Cl- channels.