Arterial Stiffness and Ambulatory Blood Pressure Measurements in Children With Familial Mediterranean Fever

Leventoglu E., BÜYÜKKARAGÖZ B., Sunar Yayla E. N., ESMERAY ŞENOL P., BAKKALOĞLU EZGÜ S. A.

CLINICAL PEDIATRICS, cilt.63, sa.9, ss.1198-1207, 2024 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 63 Sayı: 9
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1177/00099228231211705
  • Dergi Adı: CLINICAL PEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EBSCO Education Source, EMBASE, Public Affairs Index, Veterinary Science Database
  • Sayfa Sayıları: ss.1198-1207
  • Anahtar Kelimeler: ambulatory blood pressure measurement, arterial stiffness, augmentation index, familial Mediterranean fever, pulse wave velocity
  • Gazi Üniversitesi Adresli: Evet

Özet

Familial Mediterranean fever (FMF) is an autoinflammatory disease which may cause endothelial dysfunction and arterial stiffness. In this study, we evaluated patients with FMF in terms of arterial stiffness indicators and investigated whether there was any difference according to colchicine response. This is a single-center, prospective, case-control study conducted on pediatric patients with FMF. Patients were categorized into 2 groups: patients on colchicine monotherapy (group 1) and patients who used anti-interleukin-1 (IL-1) plus colchicine (group 2). Patient age, mutations in the MEFV gene, overall duration of treatments, and general characteristics of symptoms were recorded. Laboratory values in an attack-free period were noted. Pulse wave velocity (PWV) was measured in all patients. Erythrocyte sedimentation rate and C-reactive protein, nocturnal hypertension, and PWV were higher in group 2. Arterial stiffness develops due to subclinical inflammation in patients with FMF. It is more pronounced in colchicine-resistant patients.