New series of aromatic/five-membered heteroaromatic butanesulfonyl hydrazones as potent biological agents: Synthesis, physicochemical and electronic properties

HAMURCU F., Mamas S., ÖZDEMİR ÖZMEN Ü., BALABAN GÜNDÜZALP A., Şentürk O. S.

JOURNAL OF MOLECULAR STRUCTURE, cilt.1118, ss.18-27, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1118
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.molstruc.2016.03.092
  • Dergi Adı: JOURNAL OF MOLECULAR STRUCTURE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.18-27
  • Anahtar Kelimeler: Aromatic/five-membered heteroaromatic butanesulfonylhydrazones, Global reactivity descriptors, Electrochemical behavior, Cyclic voltammetry (CV), CARBONYLS M(CO)(6) M, METAL-CARBONYLS, ANTIBACTERIAL ACTIVITIES, ANTIMICROBIAL ACTIVITY, CHEMICAL-REACTIVITY, CRYSTAL-STRUCTURE, RE(CO)(5)BR, COMPLEXES, MO, CR
  • Gazi Üniversitesi Adresli: Evet

Özet

The aromatic/five-membered heteroaromatic butanesulfonylhydrazone derivatives; 5-bromosalicylalde hydebutanesulfonylhydrazone(1), 2-hydroxy-1-naphthaldehydebutane sulfonylhydrazone(2), indole-3-carboxaldehydebutanesulfonylhydrazone (3), 2-acetylfuran- carboxyaldehydebutanesulfonylhydrazone(4), 2-acetylthiophenecarboxyaldehydebutane- sulfonylhydrazone(5) and 2-acetyl-5-chlorothiophene carboxyaldehydebutanesulfonyl hydrazone (6) were synthesized by the reaction of butane sulfonic acid hydrazide with aldehydes/ketones and characterized by using elemental analysis, H-1 NMR, C-13 NMR and FT-IR technique. Their geometric parameters and electronic properties consist of global reactivity descriptors were also determined by theoretical methods. The electrochemical behavior of the butanesulfonylhydrazones were investigated by using cyclic voltammetry (CV), controlled potential electrolysis and chronoamperometry (CA) techniques. The number of electrons transferred (n), diffusion coefficient (D) and standard heterogeneous rate constants (k(s)) were determined by electrochemical methods. (C) 2016 Elsevier B.V. All rights reserved.