Gingival crevicular fluid levels of monocyte chemoattractant protein-1 and tumor necrosis factor-alpha in patients with chronic and aggressive periodontitis

Kurtis B., Tuter G., SERDAR M. A., Akdemir P., Uygur C., Firatli E., ...More

JOURNAL OF PERIODONTOLOGY, vol.76, no.11, pp.1849-1855, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 76 Issue: 11
  • Publication Date: 2005
  • Doi Number: 10.1902/jop.2005.76.11.1849
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1849-1855
  • Keywords: chemokines, gingival crevicular fluid, monocyte chemoattractant protein-1, periodontitis, tumor necrosis factor-alpha, ENDOTHELIAL-CELLS, MONONUCLEAR PHAGOCYTES, TISSUE DESTRUCTION, POTENTIAL ROLE, MESSENGER-RNA, EXPRESSION, DISEASE, CHEMOKINES, CYTOKINES, INTERLEUKIN-1-BETA
  • Gazi University Affiliated: Yes


Background: Monocyte chemoattractant protein-1 (MCP-1) is a well-known chemotactic cytokine that regulates mononuclear inflammatory cell recruitment. This recruitment has particular importance in the oral cavity because inflammatory cells will be challenged with periodontopathogenic bacteria during infections. Tumor necrosis factor-alpha (TNF-alpha) is a cytokine that induces bone resorption by stimulating proliferation and differentiation of osteoclasts' progenitors and also stimulates MCP-1 expression. The aims of this study were to investigate the presence of MCP-1 in gingival crevicular fluid (GCF) samples from patients with chronic periodontitis (CP) and aggressive periodontitis (AgP) and to examine the possible correlations between the GCF levels of MCP-1 and TNF-alpha.