The objective of this study was to evaluate the efficacy of cryosurgery on 134 different benign oral lesions in 90 patients. All lesions were treated every 2 weeks until complete regression of the lesion had been achieved. Patients were examined at 2, 7, and 10 days, 2 and 4 weeks, and 3 and 6 months after the cryosurgery. The relationship between the number of cryosurgery applications to achieve complete regression and the type of lesions was assessed for statistical significance by one-way analysis of variance and with the Scheffé test. The mean application number of the cryosurgery was 1.82±0.49 for fibroma, 2.35±1.44 for vascular lesions, 1.50±0.70 for mucocele, 2.65±1.18 for lichen planus lesions. The difference between the type of the lesion and number of application was statistically significant for all groups (p< 0.05). Our data prove that a significantly fewer number of cryosurgery treatments are required to achieve complete regression for fibroma and mucocele lesions compared to lichen planus lesions. During the follow-up period, only 7 lichen planus lesions of 76 lesions recurred. Copyright © by BIOLIFE, s.a.s.