Simple and effective cryosurgical treatment of various oral lesions

Bozkaya S., Koklu H. A. K. , Ugar D. A. , Hocaoglu T. P. , Baris E.

European Journal of Inflammation, vol.12, no.2, pp.287-295, 2014 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.1177/1721727x1401200208
  • Journal Name: European Journal of Inflammation
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.287-295
  • Keywords: Benign oral lesions, Cryosurgery, Fibroma, Lichen planus, Mucocele, Vascular lesion


The objective of this study was to evaluate the efficacy of cryosurgery on 134 different benign oral lesions in 90 patients. All lesions were treated every 2 weeks until complete regression of the lesion had been achieved. Patients were examined at 2, 7, and 10 days, 2 and 4 weeks, and 3 and 6 months after the cryosurgery. The relationship between the number of cryosurgery applications to achieve complete regression and the type of lesions was assessed for statistical significance by one-way analysis of variance and with the Scheffé test. The mean application number of the cryosurgery was 1.82±0.49 for fibroma, 2.35±1.44 for vascular lesions, 1.50±0.70 for mucocele, 2.65±1.18 for lichen planus lesions. The difference between the type of the lesion and number of application was statistically significant for all groups (p< 0.05). Our data prove that a significantly fewer number of cryosurgery treatments are required to achieve complete regression for fibroma and mucocele lesions compared to lichen planus lesions. During the follow-up period, only 7 lichen planus lesions of 76 lesions recurred. Copyright © by BIOLIFE, s.a.s.