Biochemical and structural approach to collagen synthesis under electric fields

Guler G., Atalay N., Ozogul C., Erdogan D.

GENERAL PHYSIOLOGY AND BIOPHYSICS, cilt.15, sa.6, ss.429-440, 1996 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 6
  • Basım Tarihi: 1996
  • Dergi Adı: GENERAL PHYSIOLOGY AND BIOPHYSICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.429-440
  • Gazi Üniversitesi Adresli: Evet

Özet

The effects of electric fields of different intensities and directions on the collagen synthesis of guinea pigs was studied. The effects of vertical and horizontal electric fields of 1.9 kV/m and 0.9 kV/m, generated with voltages of 300V and 150V DC, respectively, on collagen synthesis, was evaluated by assessing the amount of hydroxyproline in the liver tissue, and by histological examination of tissue samples. The Stegemann-Stalder method was used to determine hydroxyproline content of the tissues. While the 0.9 kV/m vertical and horizontal electric fields substantially decreased the amount of hydroxyproline in the liver, the 1.9 kV/m electric fields in both directions increased the hydroxyproline content. The vertical electric field was more effective than the horizontal one both in the increases and the decreases. These findings were verified histologically.