Evaluation of Superoxide Dismutase Enzyme Activity of Polymorphonuclear Leucocytes, Erythrocytes and Thrombocytes in Patients with Chronic Myeloproliferative Disorders

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Ceneli O., Haznedar R., Ongun C. O., Altan N.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, cilt.37, sa.5, ss.1365-1374, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 5
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1177/147323000903700511
  • Dergi Adı: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1365-1374
  • Anahtar Kelimeler: CHRONIC MYELOPROLIFERATIVE DISORDERS, SUPEROXIDE DISMUTASE, ANTIOXIDANT ACTIVITY, REACTIVE OXYGEN SPECIES, CHRONIC MYELOID-LEUKEMIA, POLYCYTHEMIA-VERA, GLUTATHIONE-PEROXIDASE, ANTIOXIDANT STATUS, OXIDATIVE STRESS, FREE-RADICALS, RISK-FACTORS, DIFFERENTIATION, AUTOXIDATION, NEUTROPHIL
  • Gazi Üniversitesi Adresli: Evet

Özet

This study aimed to investigate the activity of the antioxidant enzyme superoxide dismutase (SOD) in the three main cell types in chronic myeloproliferative disorders (CMPD) patients, i.e. polymorphonuclear leucocytes (PMNLs), erythrocytes and thrombocytes, prior to therapy. Patients with reactive neutrophilia (RN) and healthy volunteers were included as controls. The SOD activity of PMNLs was significantly decreased in CMPD and RN patients compared with healthy volunteers, whereas the SOD activity of erythrocytes was found to be significantly increased in patients with CMPD and RN compared with healthy volunteers. There were no significant differences in the SOD activity of thrombocytes between CMPD patients, RN. patients or healthy volunteers. This study indicates that the activity of the SOD enzyme in two cell types is different in CMPD patients compared with healthy subjects. Thus, SOD activity may be altered dependent on cell type and due to specific cell function.