Synthesis and analytical evaluation by voltammetric studies of some new indole-3-proplonamide derivatives


Suzen S., Ates-Alagoz Z., Demircigil B., Ozkan S.

FARMACO, vol.56, no.11, pp.835-840, 2001 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 11
  • Publication Date: 2001
  • Doi Number: 10.1016/s0014-827x(01)01150-8
  • Title of Journal : FARMACO
  • Page Numbers: pp.835-840
  • Keywords: indole-3-propionic derivatives, synthesis, voltammetry, analysis, MELATONIN, INDOLE, OXIDATION

Abstract

Some biologically important and melatonin-related indole-3-propionamide derivatives were synthesized. The compounds synthesized were analyzed and characterized first by NMR and mass spectrometry and then investigated by analytical voltammetric techniques. Based on this study a simple, rapid and sensitive voltammetric method was developed for the determination of the indole derivatives that are readily oxidized at the carbon-based electrodes. The oxidative behavior of the indole derivatives was studied as a function of pH at a glassy carbon electrode. The characteristics of the corresponding electrode reaction were discussed. (C) 2001 Elsevier Science S.A. All rights reserved.