Echocardiographic epicardial adipose tissue measurements provide information about cardiovascular risk in hemodialysis patients

Ulusal Okyay G., Okyay K., Polattas Solak E., ŞAHİNARSLAN A., Pasaoglu O., Ayerden Ebinc F., ...Daha Fazla

HEMODIALYSIS INTERNATIONAL, cilt.19, sa.3, ss.452-462, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1111/hdi.12276
  • Dergi Adı: HEMODIALYSIS INTERNATIONAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.452-462
  • Anahtar Kelimeler: Cardiovascular risk, epicardial adipose tissue, hemodialysis, BODY-MASS INDEX, INSULIN-RESISTANCE, OXIDATIVE STRESS, FAT, INFLAMMATION, ATHEROSCLEROSIS, MORTALITY, DISEASE, PROFILE, PLASMA
  • Gazi Üniversitesi Adresli: Evet

Özet

Epicardial adipose tissue (EAT) is a cardiovascular risk predictor in general population. However, its value has not been well validated in maintainance hemodialysis (MHD) patients. We aimed to assess associations of EAT with cardiovascular risk predictors in nondiabetic MHD patients. In this cross-sectional study, we measured EAT thickness by transthoracic echocardiography in 50 MHD patients (45.8 +/- 14.6 years of age, 37 male). Antropometric measurements, bioimpedance analysis, left ventricular (LV) mass, carotis intima media thickness, blood tests, homeostasis model assessment for insulin resistance (HOMA-IR) and hemodialysis dose by single-pool urea clearence index (spKt/V) were determined. The mean EAT thickness was 3.28 +/- 1.04mm. There were significant associations of EAT with body mass index (=0.590, P<0.001), waist circumference (=0.572, P<0.001), body fat mass (=0.562, P<0.001), percentage of body fat mass (=0.408, P=0.003), percentage of lean tissue mass (=-0.421, P=0.002), LV mass (=0.426, P=0.002), carotis intima media thickness (=0.289, P=0.042), triglyceride/high-density lipoprotein cholesterol ratio (=0.529, P<0.001), 1/HOMA-IR (=-0.386, P=0.006), and spKt/V (=-0.311, P=0.028). No association was exhibited with visfatin C, high-sensitivity C-reactive protein, interleukin-6, and tumor necrosis factor-alpha (for all, P>0.05). Body mass index, waist circumference, body fat mass, percentage of lean tissue mass, LV mass, triglyceride/high-density lipoprotein cholesterol ratio, HOMA-IR, and spKt/V appeared as independent predictors of EAT. EAT was significantly associated with body fat measures, cardiovascular risk predictors, and dialysis dose in MHD patients.