Akademik Veri Yönetim Sistemi
Fabad Journal of Pharmaceutical Sciences, cilt.31, sa.1, ss.7-14, 2006 (Scopus)
During the twentieth century, production and use of toxic chemicals have increased rapidly and thousands of chemicals have been introduced into the environment. Among them, polychlorinated biphenyl (PCB) congeners have received considerable attention in the last few decades because of their extreme persistence, bioaccumulation and toxic potential. A number of PCBs show "dioxin-like" toxicity. These PCBs are assigned with a Toxic Equivalency Factor (TEF) that relates their toxicity to that of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and are to be evaluated as dioxins. The levels of dioxin-like PCBs were determined in 45 Turkish men living in Ankara, Turkey during 2004-2005. Samples were analyzed for WHO-12 congeners (non-ortho: 77, 81, 126, 169 and mono-ortho: 105, 114, 118, 123, 156, 157, 167 and 189) using high resolution gas chromatography/high resolution mass spectrometry (HRGC/HRMS). Concentrations of Toxicity Equivalents (TEQs) in males were found between 1.1 and 16.4 pg/g fat wt in this study. The results suggest that human background contamination by dioxin-like PCBs is lower than that generally found in industrialized countries.