Quantitative determination of miconazole in creams by second order derivative spectrophotometry

Goger N., Gokcen L.

ANALYTICAL LETTERS, cilt.32, sa.13, ss.2595-2602, 1999 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 13
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1080/00032719908542990
  • Dergi Adı: ANALYTICAL LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2595-2602
  • Gazi Üniversitesi Adresli: Evet

Özet

A derivative spectrophotometry was developed to determine miconazole in cream formulations that contain benzoic acid as preservative. The procedure was based on the linear relationship in the range 100-500 mu g ml(-1) between the drug concentration and the second derivative amplitudes at 276 nm. Results of the recovery experiments performed on various amounts of benzoic acid and of the determination of miconazole in cream confirmed the applicability of the proposed method to complex formulations.