The effects of melatonin and curcumin on the expression of SIRT2, Bcl-2 and Bax in the hippocampus of adult rats

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Keskin-Aktan A., Akbulut K. G., Yazici-Mutlu C., Sonugur G., Ocal M., Akbulut H.

BRAIN RESEARCH BULLETIN, cilt.137, ss.306-310, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 137
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.brainresbull.2018.01.006
  • Dergi Adı: BRAIN RESEARCH BULLETIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.306-310
  • Anahtar Kelimeler: SIRT2, Oxidative stress, Melatonin, Curcumin, Hippocampus, Salermide, OXIDATIVE STRESS, CELL-DEATH, ALZHEIMERS-DISEASE, LIPID-PEROXIDATION, INDUCED APOPTOSIS, PC12 CELLS, BRAIN, MICE, NEURONS, PROTEIN
  • Gazi Üniversitesi Adresli: Evet

Özet

Objective: Though the mechanisms are not clearly understood, melatonin and curcumin have been reported to have neuroprotective effects. However, the mechanisms of neuroprotective effects of melatonin and curcumin in the brain are not clearly understood. In the current study, we investigated the effects of melatonin and curcumin treatments on oxidative stress parameters, the expression of SIRT2, Bcl-2 and Bax in the hippocampus.