Astragalus yukselii Karaman & Aytac (Leguminosae) is described as a new species and illustrated. The species is distributed near the town of Hadim in Konya Province (South Anatolia). Diagnostic morphological characters useful in discriminating the new species from its close relatives, A. isauricus Hub.-Mor. & V.A.Matthews and A. karjaginii (Boriss.) Boriss., are explained. Both species clearly belong to Astragalus L. sect. Macrophyllium Boiss., which is characterised by large leaves and flowers. We also present some notes on the ecology, biogeography, and conservation status of the new species.