Structural, physicochemical characterization, theoretical studies of carboxamides and their Cu(II), Zn(II) complexes having antibacterial activities against E. coli

AKTAN E., BALABAN GÜNDÜZALP A., ÖZDEMİR ÖZMEN Ü.

JOURNAL OF MOLECULAR STRUCTURE, cilt.1128, ss.775-784, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1128
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.molstruc.2016.09.013
  • Dergi Adı: JOURNAL OF MOLECULAR STRUCTURE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.775-784
  • Anahtar Kelimeler: Carboxamides, Binuclear Cu(II)-Zn(II) complexes, Antibacterial activity, DFT, METAL-AMIDE BOND, SULFONIC-ACID HYDRAZIDE, MIXED-LIGAND COMPLEXES, FT-IR, PHENYLAZOINDOLE DYES, MOLECULAR-STRUCTURE, BIOLOGICAL-ACTIVITY, CO(III) COMPLEXES, CRYSTAL-STRUCTURE, SOLID-STATE
  • Gazi Üniversitesi Adresli: Evet

Özet

The carboxamides; N,N'-bis(thiophene-2-carboxamido)-1,3-diaminopropanol (L1) and N,N'-bis(furan-2carboxamido)-1,3-diaminopropanol (L2) were synthesized and characterized using H-1 NMR, C-13 NMR, LC-MS and FT-IR spectrum. The molecular geometries of these molecules were optimized by DFT/B3LYP method with 6-311G(d,p) basis set in Gaussian 09 software. The geometrical parameters, frontier molecular orbitals (FMOs) and molecular electrostatic potential (MEP) mapped surfaces were calculated by the same basis set. Dinuclear Cu(II) and Zn(II) complexes having general formula as [MLCI](2)Cl-2.nH(2)O (in which M = Cu(II),Zn(II); n = 0,2) were also synthesized and characterized using LC-MS and FT-IR spectrum, thermogravimetric analysis (TGA/DTA curves), magnetic moments and molar conductivities. Coordination was found to be through carbonyl oxygen and two chlorine atoms as bridging in distorted tetrahedral geometry. The optimized structures, geometrical parameters, frontier molecular orbitals (FMOs) and dipole moments of metal complexes were also obtained by DFT/B3LYP method with LanL2DZ basis set. Antibacterial activities of the compounds were screened against E. coil using microdilution method (MIC's in mu g/mL). The activity results show that the corresponding compounds exhibit good to moderate antibacterial effects when compared with sulfamethoxazole and sulfisoxazole antibiotics as positive controls: Also, metal complexes have remarkable increase in their activities than parent ligands against E. coli which is mostly effected by [Cu(L2)Cl](2)Cl-2 complex as potential antibacterial agent. (C) 2016 Elsevier B.V. All rights reserved.