Trabectedin in advanced soft tissue sarcoma: case series


Demirci U., Buyukberber S., Yetisyigit T., Dizdar O., Benekli M., Alkis N., ...More

JOURNAL OF BUON, vol.17, no.3, pp.591-592, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 3
  • Publication Date: 2012
  • Title of Journal : JOURNAL OF BUON
  • Page Numbers: pp.591-592

Abstract

The prognosis of advanced soft tissue sarcomas (STS) is poor The median overall survival (OS) is 6 months in unresectable and metastatic STS that progress after treatment with anthracyclines and ifosfamide. Trabectedin is an alkylating agent, effective in advanced STS, especially in leiomyosarcoma and liposarcoma. In the present study, the effectiveness and safety of trabectedin was retrospectively evaluated in 8 unresectable and metastatic STS patients. Their median age was 47 years. The median progression free survival (PFS) was 3.75 months and the median OS 15 months in relapse or progression after anthracyclines and/or ifosfamide. Toxicities were mainly hematologic. In the present study, trabectedin showed efficacy in different histological subtypes of sarcomas like liposarcoma and leiomyosarcoma.