Familial aggregation in Behcet's Disease: Sibling history as a risk factor for Neuro-Behcet
IRISH JOURNAL OF MEDICAL SCIENCE, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2026
- Doi Numarası: 10.1007/s11845-026-04576-9
- Dergi Adı: IRISH JOURNAL OF MEDICAL SCIENCE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest)
- Gazi Üniversitesi Adresli: Evet
Özet
Background Behcet's disease (BD) is a multisystem inflammatory disorder in which both genetic predisposition and environmental factors contribute to its pathogenesis. Aims This study aimed to investigate the impact of sibling history on organ involvement and clinical features in BD. Methods A total of 891 patients diagnosed with Beh & ccedil;et's disease were enrolled in the study. Patients were stratified according to the presence and degree of familial aggregation: 651 had no family history of Behcet's disease (sporadic BD), while 240 reported a positive family history, of whom 70 had an affected sibling (BDw/SH). Demographic characteristics, clinical manifestations, and laboratory parameters were systematically retrieved from patients' medical records. Logistic regression analyses were performed to identify independent predictors of major organ involvement. Multivariable models were adjusted for relevant demographic and clinical covariates. Results Age, sex, body mass index (BMI), and smoking status were similar in patients with a sibling history of Beh & ccedil;et's disease (n = 70) and those without family history (n = 651) (p > 0.05). Among the clinical manifestations, the frequency of neurological involvement was significantly higher in patients with a sibling history of Behcet's disease compared to those without family history ( 20% vs. 7.5%, p < 0.001), with a threefold increased risk in multivariate analysis (OR: 3.01, CI95%:1.54-5.88). Conclusion These findings demonstrate that the presence of an affected sibling increases the risk of neurological involvement by 3-fold. Early recognition of neuro-Beh & ccedil;et is critical; hence, clinicians should remain alert to its possible neurological manifestations in individuals with a sibling history.