Effects of intravenous ibuprofen and lornoxicam on erythrocyte deformability in rats undergoing hind limb ischemia reperfusion injury

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Sivgin V., Kucuk A., Comu F. M. , Kosem B., Kartal S., Turgut H. C. , ...More

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, vol.117, no.12, pp.722-725, 2016 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 117 Issue: 12
  • Publication Date: 2016
  • Doi Number: 10.4149/bll_2016_138
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.722-725
  • Keywords: ischemia reperfusion, erythrocyte deformability, intravenous ibuprofen, lornoxicam, rat, RED-BLOOD-CELL, SKELETAL-MUSCLE, FLOW, LUNG


BACKGROUNDAND AIM: Acute hind limb ischemia reperfusion (I/R) injury is a common consequence of abdominal aorta cross-clamping during aortic surgery. Erythrocyte deformability is affected by I/R process and may lead to increased tissue and organ injury. Lornoxicam and intravenous ibuprofen are becoming commonly used as non-steroidal anti-inflammatory drugs (NSAID) for postoperative analgesia. In this study, we aimed to investigate the effects of lornoxicam (2 mg/kg iv) and intravenous ibuprofen (30 mg/kg iv) on erythrocyte deformability in I/R model in rats.