Differential pulse polarographic determination of moxifloxacin hydrochloride in pharmaceuticals and biological fluids


Inam R. , Mercan H., Yilmaz E., Uslu B.

ANALYTICAL LETTERS, vol.40, no.3, pp.529-546, 2007 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 3
  • Publication Date: 2007
  • Doi Number: 10.1080/00032710600964817
  • Title of Journal : ANALYTICAL LETTERS
  • Page Numbers: pp.529-546
  • Keywords: moxifloxacin, differential pulse polarography, pharmaceutics, serum, urine, PERFORMANCE LIQUID-CHROMATOGRAPHY, HUMAN PLASMA, VOLTAMMETRY, GATIFLOXACIN, LEVOFLOXACIN, ELECTRODES, FLEROXACIN, TABLETS, MEDIA, ACID

Abstract

A simple, fast, sensitive and fully validated differential pulse polarographic ( DPP) method for the determination of trace amounts of moxifloxacin in pharmaceutics, serum and urine is reported. Moxifloxacin exhibited irreversible cathodic peak over the pH 5.00 - 11.00 in Britton - Robinson ( B - R) buffer. At pH 10.00 ( the analytical pH), a well-defined peak at -1.61 V versus saturated calomel electrode was obtained. The current has been characterized as being diffusion-controlled process. The diffusion current constant (i(d)) was 1.48 +/- 0.12 and the current - concentration plot was rectilinear over the range from 5 x 10(-7) to 1 x 10(-4) M with correlation coefficient (n = 10) of 0.995.