Cranial bone regeneration via BMP-2 encoding mesenchymal stem cells

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Vural A. C., ODABAŞ S., KORKUSUZ P., YAR SAĞLAM A. S., BİLGİÇ E., ÇAVUŞOĞLU T., ...More

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, vol.45, no.3, pp.544-550, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.3109/21691401.2016.1160918
  • Journal Name: ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.544-550
  • Keywords: Bone morphogenetic protein-2, cranial bone regeneration, critical size defect, mesenchymal stem cell, transfection, MORPHOGENETIC PROTEIN-2, GROWTH-FACTOR, IN-VIVO, SCAFFOLDS, CRYOGELS, DEFECTS
  • Gazi University Affiliated: Yes

Abstract

Cranial bone repair and regeneration via tissue engineering principles has attracted a great deal of interest from researchers during last decade. Here, within this study, 6mm critical-sized bone defect regeneration via genetically modified mesenchymal stem cells (MSC) were monitored up to 4 months. Cranial bone repair and new bone formations were evaluated by histological staining and real time PCR analysis in five different groups including autograft and bone morphogenetic protein-2 (BMP-2) transfected MSC groups. Results presented here indicate a proper cranial regeneration in autograft groups and a prospering regeneration for hBMP-2 encoding mesenchymal stem cells.