Cytoreductive surgeries (CRS) are the common management modality for advanced cancers. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy offer survival advantages in well selected patients with peritoneal tumors. These procedures are technically challenging with potential for high perioperative morbidity and mortality. The complexity of CRS/HIPEC requires surgical specialization. In this case report, we wanted to dicuss anesthesia management in a 73 year old woman with ovarian cancer who underwent CRS/HIPEC under general anesthesia.