Choroidal Neovascular Membrane in Age-Related Macular Degeneration is Associated with Increased Interleukin-6

Yildirim Z., Ucgun N. I., Yildirim F., SEPİCİ DİNÇEL A.

INTERNATIONAL JOURNAL OF GERONTOLOGY, cilt.6, sa.2, ss.101-104, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 6 Sayı: 2
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.ijge.2012.01.018
  • Dergi Adı: INTERNATIONAL JOURNAL OF GERONTOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.101-104
  • Anahtar Kelimeler: AMD, IL-6, IL-1 beta, inflammation, VEGF, ENDOTHELIAL GROWTH-FACTOR, NITRIC-OXIDE SYNTHASE, C-REACTIVE PROTEIN, COMPLEMENT ACTIVATION, EPITHELIAL-CELLS, DRUSEN, MACULOPATHY, EXPRESSION, ATHEROSCLEROSIS, PERMEABILITY
  • Gazi Üniversitesi Adresli: Hayır

Özet

Background: Age-related macular degeneration (AMD) is the leading cause of irreversible visual impairment and blindness among persons aged 60 years and older. Although inflammation has been postulated to have a role in the pathogenesis of AMD, epidemiologic studies have not shown a relationship between systemic inflammation or presence of inflammatory markers at AMD. The aim of our study was to evaluate the differences in various types of cytokines and intracelluler signaling molecules for the onset and progression of AMD.