Oxidative stress and Parkinson disease Oksidatif Stres ve Parkinson hastaliği


Aslan S. N. , KARAHALİL B.

Ankara Universitesi Eczacilik Fakultesi Dergisi, vol.43, no.1, pp.94-116, 2019 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.33483/jfpau.519964
  • Journal Name: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Journal Indexes: Scopus
  • Page Numbers: pp.94-116
  • Keywords: Aging, Neurodegenerative disease, Oxidative stress, Parkinson's disease (PD), Reactive oxygen species (ROS)
  • Gazi University Affiliated: Yes

Abstract

© 2019 University of Ankara. All rights reserved.Objective: Parkinson's Disease (PD) is a chronic and progressive neurodegenerative disease in the brain associated with the loss of dopaminergic neurons. Old age is the only proven factor in the development of PD. It is thought that oxidative stress which is more triggered in old age plays a vital role in the formation of dopaminergic neurotoxicity. In this review, the relationship between oxidative stress and PD will be examined. Material and Method: The databases in the health sciences field were used to compile the studies conducted to determine the relationship between PH and oxidative stress. Previously published articles such as Web of Science have been used. Result and Discussion: Parkinson's is a neurodegenerative disease resulting from the complex interaction of genetic and environmental factors that affect on many basic cellular process. Oxidative stress threatens genetic integrity and contributes to the development of PH. Avoiding damage products due to oxidative stress and drawing a protective treatment protocol may be a crucial strategy for maintaining healthy brain function and protecting the organism from neurodegenerative diseases such as Parkinson's disease.