Human Adenovirus: An Unusual Causative Agent for Acute Retinal Necrosis Presented with Central Retinal Vascular Occlusion

ÖZDEMİR H. B., Ozdal P. C.

OCULAR IMMUNOLOGY AND INFLAMMATION, vol.28, no.5, pp.749-753, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Letter
  • Volume: 28 Issue: 5
  • Publication Date: 2020
  • Doi Number: 10.1080/09273948.2019.1624780
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.749-753
  • Keywords: Acute retinal necrosis, adenovirus, ARN, central retinal vascular occlusion, DIAGNOSTIC-CRITERIA
  • Gazi University Affiliated: Yes


Purpose: We describe a case of acute retinal necrosis (ARN) with central retinal vascular occlusion caused by human adenovirus (HAdV). Case Report: A 41-year-old man presented with a sudden decrease of visual acuity in his right eye since seven days. Visual acuity was hand movements and ophthalmic examination of the right eye revealed diffuse hemorrhagic retinal vasculitis with panuveitis. He was clinically diagnosed as ARN with central retinal vascular occlusion. An anterior chamber paracentesis and intravitreal ganciclovir injection were performed and intravenous ganciclovir has been initiated immediately. Polymerase chain reaction (PCR) analysis of aqueous humor identified HAdV DNA as a causative agent. Oral prednisolone was added to treatment 5 days after antiviral therapy. After 10 days of intravenous ganciclovir therapy, oral valganciclovir was given for 6 months. No recurrence or retinal detachment occurred during follow-up. Conclusion: HAdV known to cause acute epibulbar infections of the eye may also cause intraocular inflammation such as ARN.