Effects of vitamin C and n-acetylcysteine against cyclophosphamide-induced genotoxicity in exfoliated bladder cells of mice in vivo

Gurbuz N., Ozkul A., Burgaz S.

JOURNAL OF BUON, vol.14, no.4, pp.647-652, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 4
  • Publication Date: 2009
  • Title of Journal : JOURNAL OF BUON
  • Page Numbers: pp.647-652
  • Keywords: chemoprevention, exfoliated bladder cells, genotoxicity, micronucleus, N-acetylcysteine, vitamin C, ASCORBIC-ACID, MICRONUCLEI FREQUENCIES, INDUCED UROTOXICITY, EPITHELIAL-CELLS, BETA-CAROTENE, DNA-DAMAGE, CLASTOGENICITY, CHEMOPREVENTION, PREVENTION, CANCER

Abstract

Purpose: To investigate the effects of vitamin C and N-acetylcysteine (NAC) against cyclophosphamide (CP)-induced genotoxic damage in exfoliated bladder cells of mice by micronucleus (MN) assay.