Acute and chronic effects of different concentrations of free fatty acids on the insulin secreting function of islets

Ayvaz G., Toruner F. S., Karakoc A., Yetkin I., Cakir N., Arslan M.

DIABETES & METABOLISM, cilt.28, sa.6, 2002 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 6
  • Basım Tarihi: 2002
  • Dergi Adı: DIABETES & METABOLISM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: FFA, islet, insulin secretion, lipotoxicity, PANCREATIC-ISLETS, RAT ISLETS, IN-VIVO, GLUCOSE, RELEASE, METABOLISM, ELEVATION, HUMANS
  • Gazi Üniversitesi Adresli: Evet

Özet

Introduction: Lipotoxic effects of free fatty acids (FFAs) on insulin secreting function of islet beta-cells have been demonstrated in recent studies. This toxic effect is especially prominent on postprandial hypertriglyceridemic period. Hypertriglyceridemia and high FFAs levels are the most common metabolic disturbances seen in diabetes mellitus (DM), in particular in uncontrolled cases.