Acute and chronic effects of different concentrations of free fatty acids on the insulin secreting function of islets

Ayvaz G., Toruner F. S., Karakoc A., Yetkin I., Cakir N., Arslan M.

DIABETES & METABOLISM, vol.28, no.6, 2002 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 6
  • Publication Date: 2002
  • Journal Name: DIABETES & METABOLISM
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: FFA, islet, insulin secretion, lipotoxicity, PANCREATIC-ISLETS, RAT ISLETS, IN-VIVO, GLUCOSE, RELEASE, METABOLISM, ELEVATION, HUMANS
  • Gazi University Affiliated: Yes

Abstract

Introduction: Lipotoxic effects of free fatty acids (FFAs) on insulin secreting function of islet beta-cells have been demonstrated in recent studies. This toxic effect is especially prominent on postprandial hypertriglyceridemic period. Hypertriglyceridemia and high FFAs levels are the most common metabolic disturbances seen in diabetes mellitus (DM), in particular in uncontrolled cases.