DIABETES & METABOLISM, vol.28, no.6, 2002 (SCI-Expanded)
Article / Article
DIABETES & METABOLISM
Science Citation Index Expanded (SCI-EXPANDED), Scopus
FFA, islet, insulin secretion, lipotoxicity, PANCREATIC-ISLETS, RAT ISLETS, IN-VIVO, GLUCOSE, RELEASE, METABOLISM, ELEVATION, HUMANS
Gazi University Affiliated:
Introduction: Lipotoxic effects of free fatty acids (FFAs) on insulin secreting function of islet beta-cells have been demonstrated in recent studies. This toxic effect is especially prominent on postprandial hypertriglyceridemic period. Hypertriglyceridemia and high FFAs levels are the most common metabolic disturbances seen in diabetes mellitus (DM), in particular in uncontrolled cases.