Easier and more explanatory indices by integrating leukocyte lymphocyte ratio (LLR) and prognostic nutritional index (PNI) to IPS systems in cases with classical Hodgkin lymphoma


PAYDAŞ S., Lacin S., Dogan M., BARIŞTA İ., Yildiz B., SEYDAOĞLU G., ...More

LEUKEMIA RESEARCH, vol.107, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 107
  • Publication Date: 2021
  • Doi Number: 10.1016/j.leukres.2021.106586
  • Title of Journal : LEUKEMIA RESEARCH
  • Keywords: Hodgkin lymphoma, IPS-4, PNI, LLR, Inflammatory indices, NEUTROPHIL, PREDICTS, SCORE, SURVIVAL

Abstract

The aim of this study is to determine the power of he international prognostic scoring systems (IPS-7 and IPS-3) and to obtain indices by integrating leukocyte lymphocyte ratio (LLR) and prognostic nutritional index (PNI) factors as prognostic indicators in cases with classical Hodgkin lymphoma (cHL). 1012 patients with cHL were evaluated with 2 different IPS-4 scores with four parameters: stage, age, hemoglobin level, and either LLR or PNI. Statistical package SPSS v 22.0 was used. Two different Cox regression models were obtained for OS and PFS. Model 1 showed LLR >= 5,8 as the highest risk for OS and anemia as the highest risk for PFS. Model 2 showed PNI <= 45,2 as the highest risk for OS and anemia as the highest risk for PFS. IPS-4 scores obtained by integrating either LLR or PNI to IPS-3 integration of a biologic parameter either LLR or PNI need to be determined with clinical risk scoring parameters.