Beam-columns are structural members subjected to a combination of axial and bending forces. Lateral-torsional buckling is one of the main failure modes. Beam-columns that are bent about its strong axis may buckle out of the plane by deflecting laterally and twisting as the values of the applied loads reach a limiting state. Lateral-torsional buckling failure occurs suddenly in beam-column elements with a much greater in-plane bending stiffness than torsional or lateral bending stiffness. This study intends to establish a unique convenient closed-form equation that it can be used for calculating critical elastic lateral-torsional buckling load of beam-column in the presence of a known axial load. The presented equation includes first order bending distribution, the position of the loads acting transversely on the beam-column and mono-symmetry property of the section. Effects of axial loads, slenderness and load positions on lateral torsional buckling behavior of beam-columns are investigated. The proposed solutions are compared to finite element simulations where thin-walled shell elements including warping are used. Good agreement between the analytical and the numerical solutions is demonstrated. It is found out that the lateral-torsional buckling load of beam-columns with mono-symmetric sections can be determined by the presented equation and can be safely used in design procedures.