Serum ciliary neurotrophic factor levels in children with attention deficit hyperactivity disorder

Buyuktaskin D., Güney E., Gulbahar Ö., Özaslan A., Arslan B.

INTERNATIONAL JOURNAL OF NEUROSCIENCE, cilt.134, sa.4, ss.313-317, 2024 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 134 Sayı: 4
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1080/00207454.2022.2100782
  • Dergi Adı: INTERNATIONAL JOURNAL OF NEUROSCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE, Psycinfo
  • Sayfa Sayıları: ss.313-317
  • Anahtar Kelimeler: Neurodevelopmental disorders, neurotrophins, dopamine, biomarkers, neurochemistry, NERVE GROWTH-FACTOR, DEFICIT/HYPERACTIVITY DISORDER, FACTOR BDNF, OXIDATIVE STRESS, ASSOCIATION, TEACHER, RECEPTOR, PARENT, ADULT, GENES
  • Gazi Üniversitesi Adresli: Evet

Özet

Purpose/aim of the study: The study aimed to highlight the possible role of ciliary neurotrophic factor (CNTF) in the pathophysiology of attention deficit hyperactivity disorder (ADHD) and determine whether CNTF can be used as a biomarker for ADHD.Materials and methods: Patients with a diagnosis of ADHD and neurotypical subjects aged 6-12 years were recruited prospectively. The study applied Conners' Teacher Rating Scale (CTRS) to determine the patients' ADHD predominance and severity. Serum CNTF levels were measured with an enzyme-linked immunosorbent assay (ELISA) kit.Results: A total of 43 ADHD patients and 33 healthy controls were included in the study. A significant difference was found between the serum CNTF levels of the ADHD patients (22.17 pg/ml) and the controls (22.80 pg/ml). Correlations between the CNTF levels and CTRS scores were not significant.Conclusions: The study identified an alteration of serum CNTF levels in ADHD patients and thus asserted a link between CNTF and ADHD pathophysiology; children with ADHD had significantly lower serum CNTF levels compared to the neurotypical controls. Further research is needed to understand the mechanisms of CNTF.