HPV types and E6/E7 mRNA expression in cervical samples from Turkish women with abnormal cytology in Ankara, Turkey

Tuney I., Altay A., ERGÜNAY K., ÖNDER S. Ç., USUBÜTÜN A., SALMAN M. C., ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.47, no.1, pp.194-200, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.3906/sag-1508-155
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.194-200
  • Keywords: Cervical cancer, cytology, HPV DNA test, E6/E7 mRNA, HUMAN-PAPILLOMAVIRUS INFECTION, INTRAEPITHELIAL NEOPLASIA, NATURAL-HISTORY, CANCER, DNA, CLASSIFICATION, PERFORMANCE, LESIONS, RISK
  • Gazi University Affiliated: Yes

Abstract

Background/aim: Human papillomaviruses have been established as a risk factor for invasive carcinoma of the uterine cervix. HPV E6/E7 oncogene expression has recently emerged as a promising biomarker to determine the risk for progression to high-grade cervical lesions. The aim of this study was to evaluate HPV mRNA and DNA detection in samples with abnormal cytology.