The impact of detoxifying and repair gene polymorphisms and the levels of serum ROS in the susceptibility to multiple sclerosis

KARAHALİL B., Orhan G., Ak F.

CLINICAL NEUROLOGY AND NEUROSURGERY, cilt.139, ss.288-294, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 139
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.clineuro.2015.10.028
  • Dergi Adı: CLINICAL NEUROLOGY AND NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.288-294
  • Anahtar Kelimeler: Multiple sclerosis, GSTs, XRCC1, OGG1, Polymorphism, Reactive oxygen species, OXIDATIVE DNA-DAMAGE, S-TRANSFERASE T1, NEURODEGENERATIVE DISEASES, STRESS, GSTM1, INJURY, GSTT1
  • Gazi Üniversitesi Adresli: Evet

Özet

Objective: Multiple sclerosis (MS) is an autoimmune neurodegenerative disease with unknown etiology. Oxidative stress (OS) has been implicated to play a role in its cause; therefore, antioxidants and repair systems may help in restoring oxidant-antioxidant balance. Since polymorphisms in DNA repair genes can result in reduced DNA repair capacity, it is important to investigate its association with OS products to demonstrate the impact of individual susceptibility. Our aim is to examine whether a defect in one of the detoxifying and DNA repair enzyme systems could explain the association between MS and exposure to OS products.