The impact of detoxifying and repair gene polymorphisms and the levels of serum ROS in the susceptibility to multiple sclerosis

KARAHALİL B., Orhan G., Ak F.

CLINICAL NEUROLOGY AND NEUROSURGERY, vol.139, pp.288-294, 2015 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 139
  • Publication Date: 2015
  • Doi Number: 10.1016/j.clineuro.2015.10.028
  • Journal Name: CLINICAL NEUROLOGY AND NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.288-294
  • Keywords: Multiple sclerosis, GSTs, XRCC1, OGG1, Polymorphism, Reactive oxygen species, OXIDATIVE DNA-DAMAGE, S-TRANSFERASE T1, NEURODEGENERATIVE DISEASES, STRESS, GSTM1, INJURY, GSTT1
  • Gazi University Affiliated: Yes

Abstract

Objective: Multiple sclerosis (MS) is an autoimmune neurodegenerative disease with unknown etiology. Oxidative stress (OS) has been implicated to play a role in its cause; therefore, antioxidants and repair systems may help in restoring oxidant-antioxidant balance. Since polymorphisms in DNA repair genes can result in reduced DNA repair capacity, it is important to investigate its association with OS products to demonstrate the impact of individual susceptibility. Our aim is to examine whether a defect in one of the detoxifying and DNA repair enzyme systems could explain the association between MS and exposure to OS products.