Effect of picroside II on hind limb ischemia reperfusion injury in rats
DRUG DESIGN DEVELOPMENT AND THERAPY, cilt.11, ss.1917-1925, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 11
- Basım Tarihi: 2017
- Doi Numarası: 10.2147/dddt.s132401
- Dergi Adı: DRUG DESIGN DEVELOPMENT AND THERAPY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1917-1925
- Anahtar Kelimeler: ischemia reperfusion, picroside II, hind limb skeletal muscle, TOS, TAS, TOTAL ANTIOXIDANT CAPACITY, SKELETAL-MUSCLE, MYOCARDIAL-ISCHEMIA, PICRORHIZA-KURROA, RENAL INJURY, VITAMIN-C, MODEL, LUNG, ILOPROST
- Gazi Üniversitesi Adresli: Evet
Özet
Introduction: Many structural and functional damages are observed in cells and tissues after reperfusion of previously viable ischemic tissues. Acute ischemia reperfusion (I/R) injury of lower extremities occurs especially when a temporary cross-clamp is applied to the abdominal aorta during aortic surgery. Research regarding the treatment of I/R injury has been increasing day-by-day. In this study, we aimed to investigate the effect of picroside II on skeletal muscle of rats experiencing simulated I/R.