Effect of picroside II on hind limb ischemia reperfusion injury in rats

Kilic Y., ÖZER A., TATAR T., ZOR M. H., Kirisci M., Kartal H., ...Daha Fazla

DRUG DESIGN DEVELOPMENT AND THERAPY, cilt.11, ss.1917-1925, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11
  • Basım Tarihi: 2017
  • Doi Numarası: 10.2147/dddt.s132401
  • Dergi Adı: DRUG DESIGN DEVELOPMENT AND THERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1917-1925
  • Anahtar Kelimeler: ischemia reperfusion, picroside II, hind limb skeletal muscle, TOS, TAS, TOTAL ANTIOXIDANT CAPACITY, SKELETAL-MUSCLE, MYOCARDIAL-ISCHEMIA, PICRORHIZA-KURROA, RENAL INJURY, VITAMIN-C, MODEL, LUNG, ILOPROST
  • Gazi Üniversitesi Adresli: Evet

Özet

Introduction: Many structural and functional damages are observed in cells and tissues after reperfusion of previously viable ischemic tissues. Acute ischemia reperfusion (I/R) injury of lower extremities occurs especially when a temporary cross-clamp is applied to the abdominal aorta during aortic surgery. Research regarding the treatment of I/R injury has been increasing day-by-day. In this study, we aimed to investigate the effect of picroside II on skeletal muscle of rats experiencing simulated I/R.