Involvement of galectin-3 in cadmium-induced cardiac toxicity


YAZIHAN N., Kocak M. K. , Akcil E., Erdem O., Sayal A., Guven C., ...More

ANADOLU KARDIYOLOJI DERGISI-THE ANATOLIAN JOURNAL OF CARDIOLOGY, vol.11, no.6, pp.479-484, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 6
  • Publication Date: 2011
  • Doi Number: 10.5152/akd.2011.130
  • Journal Name: ANADOLU KARDIYOLOJI DERGISI-THE ANATOLIAN JOURNAL OF CARDIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.479-484
  • Keywords: Cadmium, heart, galectin-3, caspase-3, tumor necrosis factor alpha, interleukin-6, HEART-FAILURE, MICE, MACROPHAGES, DYSFUNCTION, EXPRESSION, EXPOSURE, FIBROSIS
  • Gazi University Affiliated: Yes

Abstract

Objective: Accumulation of the wide spread environmental toxin cadmium (Cd) in tissues results in toxicity. Heart is one of the most effected tissues. Cd exposure induces inflammation in effected tissues. The present study was focused to evaluate roles of tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) in Cd toxicity and their relationships with galectin-3 levels.