Involvement of galectin-3 in cadmium-induced cardiac toxicity


YAZIHAN N., Kocak M. K. , Akcil E., Erdem O., Sayal A., Guven C., ...More

ANADOLU KARDIYOLOJI DERGISI-THE ANATOLIAN JOURNAL OF CARDIOLOGY, vol.11, no.6, pp.479-484, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 6
  • Publication Date: 2011
  • Doi Number: 10.5152/akd.2011.130
  • Title of Journal : ANADOLU KARDIYOLOJI DERGISI-THE ANATOLIAN JOURNAL OF CARDIOLOGY
  • Page Numbers: pp.479-484
  • Keywords: Cadmium, heart, galectin-3, caspase-3, tumor necrosis factor alpha, interleukin-6, HEART-FAILURE, MICE, MACROPHAGES, DYSFUNCTION, EXPRESSION, EXPOSURE, FIBROSIS

Abstract

Objective: Accumulation of the wide spread environmental toxin cadmium (Cd) in tissues results in toxicity. Heart is one of the most effected tissues. Cd exposure induces inflammation in effected tissues. The present study was focused to evaluate roles of tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) in Cd toxicity and their relationships with galectin-3 levels.