Cholesterol Levels in Patients with Chronic Lymphocytic Leukemia

YAVAŞOĞLU İ., Sargin G., Yilmaz F., Altindag S., Akgun G., TOMBAK A., ...Daha Fazla

JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION, cilt.109, sa.1, ss.23-27, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 109 Sayı: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.jnma.2016.11.006
  • Dergi Adı: JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.23-27
  • Anahtar Kelimeler: Blood lipid profiles, Cholesterol levels, Chronic lymphocytic leukemia, DENSITY-LIPOPROTEIN CHOLESTEROL, CANCER-PATIENTS, SERUM-CHOLESTEROL, CELLS, RECEPTOR, PLASMA, GROWTH, RISK, CHEMOTHERAPY, METABOLISM
  • Gazi Üniversitesi Adresli: Evet

Özet

Low cholesterol levels may be accompanied by solid tumors or hematological malignancies such as multiple myeloma. Decreased cholesterol levels have been reported in some experimental studies about chronic lymphocytic leukemia (CLL). It may be associated with tumoral cell metabolism. Herein, we examine blood lipid profiles of patients with newly diagnosed CLL (284 male, 276 female, mean age 64 +/- 11 years) as defined by National Cancer Institute criteria. The control group consisted of 71 healthy subjects with mean age 55 +/- 9 years (28 male, 43 females). 60% of patients with Binet A, while 25% were Binet C. Decreased levels of total cholesterol, high density lipoprotein (HDL) and low density lipoprotein (LDL) were observed in patients with CLL than control group (p < 0,001). There was no statistical significance between CLL and control group for triglycerides (TG) and very low density lipoprotein (VLDL), also between HDL-C, VLDL, TG and grades. Cholesterol may metabolized by abnormal lymphocytes in CLL patients.