Effects of fetuin-A with diverse functions and multiple mechanisms on human health

İçer M. A., Yıldıran H.

CLINICAL BIOCHEMISTRY, vol.88, pp.1-10, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 88
  • Publication Date: 2021
  • Doi Number: 10.1016/j.clinbiochem.2020.11.004
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.1-10
  • Keywords: Fetuin-A, Biomarker, Medicinal biochemistry, Calcification, Insulin resistance, Cancer
  • Gazi University Affiliated: Yes


Fetuin-A (Alfa 2-Heremans-Schmid) is a glycoprotein that is mainly synthesized by hepatocytes and then released into the bloodstream. While fetuin-A, a multifunctional protein, has inhibitory effects on health in the processes of calcification, mineralization, coronary artery calcification (CAC), and kidney stone formation by various mechanisms, it has such stimulatory effects as obesity, diabetes, and tumor progression processes. Fetuin-A produces these effects on the organism mainly by playing a role in the secretion levels of some inflammatory cytokines and exosomes, preventing unwanted calcification, inhibiting the autophosphorylation of tyrosine kinase, suppressing the release of adiponectin and peroxisome proliferator-activated receptor-gamma (PPAR gamma), activating the toll-like receptor 4 (TLR-4), triggering the phosphatidylinositol 3 (PI3) kinase/Akt signaling pathway and cell proliferation, and mimicking the transforming growth factor-beta (TGF-beta) receptor. In the present review, fetuinA was examined in a wide perspective from the structure and release of fetuin-A to its effects on health.