Role of interleukin 8 in the pathogenesis of proliferative vitreoretinopathy


Aksunger A., Or M., Okur H., Hasanreisoglu B., Akbatur H.

OPHTHALMOLOGICA, vol.211, no.4, pp.223-225, 1997 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 211 Issue: 4
  • Publication Date: 1997
  • Doi Number: 10.1159/000310794
  • Title of Journal : OPHTHALMOLOGICA
  • Page Numbers: pp.223-225

Abstract

We investigated the role of interleukin 8 (IL-8) in the pathogenesis of proliferative vitreoretinopathy (PVR). The IL-8 level in the vitreous and the blood of 20 patients with PVR was measured by a specific enzyme-linked immunoassay method. Vitreous from cadaver eyes (n = 20) was used as the control. The IL-8 level in the vitreous was between 31.3 and 65 pg/ml in 40% of eyes with PVR. IL-8 was detected neither in the blood of the patients with PVR nor in the vitreous from cadaver eyes. IL-8 levels in the vitreous did not correlate with either the grade of PVR or the duration of symptoms. These results suggest that IL-8 may play a role in the pathogenesis of PVR.