The gender differences in the relaxation to levosimendan of human internal mammary artery


AKAR F., Manavbasi Y., Parlar A. I., Ulus A. T., Katircioglu S. F.

CARDIOVASCULAR DRUGS AND THERAPY, vol.21, no.5, pp.331-338, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 5
  • Publication Date: 2007
  • Doi Number: 10.1007/s10557-007-6047-x
  • Journal Name: CARDIOVASCULAR DRUGS AND THERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.331-338
  • Keywords: levosimendan, gender, human artery, potassium channels, relaxation, SPONTANEOUSLY HYPERTENSIVE-RATS, ISOLATED CORONARY-ARTERY, SMOOTH-MUSCLE, SEX-HORMONES, INTRAVENOUS LEVOSIMENDAN, POTASSIUM CHANNELS, CALCIUM SENSITIZER, HEART-FAILURE, BYPASS GRAFT, K+ CHANNEL
  • Gazi University Affiliated: Yes

Abstract

Purpose The mechanism of the vasorelaxation to levosimendan varies depending on the vascular bed and species studied. Here, we examined the vasorelaxation to levosimendan as well as its modification by various potassium channel antagonists in human internal mammary artery (IMA) obtained from male and female patients.